Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 20/20 | 0.75 |
| ▸ | KRAS | P01116 | 5/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27146978 | 1.00 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL23520900 | 1.00 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL30019602 | 0.92 | SOS1 (0.78) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL26626764 | 0.90 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL26626767 | 0.90 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL30630988 | 0.90 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL30630967 | 0.89 | SOS1 (0.82) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL26626750 | 0.89 | SOS1 (0.82) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL26626743 | 0.89 | SOS1 (0.82) | SOS1KRASCYP3A4CYP2C8CYP2D6 | |
| SCHEMBL30630972 | 0.88 | SOS1 (0.75) | SOS1KRASCYP3A4CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232108-B | SOS1 degradation agent and preparation method and application thereof | 领泰生物医药(绍兴)有限公司 | 2025-04-18 | — | — | CN | disclosed |
| CN-115232114-B | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2023-12-19 | — | — | CN | disclosed |
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223039-A1 | SOS1 DEGRADER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115232114-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115232111-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115232108-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |