Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 9/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 8/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25596174 | 1.00 | SRD5A1 (0.41) | SRD5A1SRD5A2DDB1CRBNTTR | |
| SCHEMBL29892316 | 0.87 | CRBN (0.41) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL25256759 | 0.87 | CRBN (0.41) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL29318952 | 0.86 | DDB1 (0.49) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL30267074 | 0.86 | DDB1 (0.49) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL30014315 | 0.85 | DDB1 (0.37) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL25596158 | 0.85 | DDB1 (0.37) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL31677278 | 0.85 | DDB1 (0.40) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL31524286 | 0.85 | DDB1 (0.40) | SRD5A1SRD5A2DDB1CRBN | |
| SCHEMBL23122938 | 0.85 | DDB1 (0.40) | SRD5A1SRD5A2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223039-A1 | SOS1 DEGRADER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115232114-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115232111-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115232108-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |