Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31386725 | 1.00 | PARP1 (0.50) | PARP1CSNK2A1CREBBPPIK3CAALDH1A1 | |
| SCHEMBL29203506 | 0.84 | PARP1 (0.46) | PARP1CSNK2A1PIK3CAALDH1A1KDM4E | |
| SCHEMBL31386916 | 0.79 | PARP1 (0.47) | PARP1CSNK2A1CREBBPALDH1A1KDM4E | |
| SCHEMBL31386715 | 0.79 | PARP1 (0.47) | PARP1CSNK2A1CREBBPALDH1A1KDM4E | |
| SCHEMBL31271560 | 0.78 | PARP1 (0.48) | PARP1CSNK2A1CREBBPALDH1A1KDM4E | |
| SCHEMBL30577717 | 0.78 | PARP1 (0.48) | PARP1CSNK2A1CREBBPALDH1A1KDM4E | |
| SCHEMBL30576717 | 0.76 | DAO (0.47) | ALDH1A1KDM4EHSD17B10KMT2AHPGD | |
| SCHEMBL29078234 | 0.76 | DAO (0.47) | ALDH1A1KDM4EHSD17B10KMT2AHPGD | |
| SCHEMBL7980590 | 0.76 | PARP1 (0.52) | PARP1CSNK2A1CREBBPALDH1A1KDM4E | |
| SCHEMBL29892956 | 0.76 | PARP1 (0.52) | PARP1CSNK2A1CREBBPALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392425-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF | Impact Therapeutics (Shanghai), Inc. (CN) | 2024-07-03 | — | — | EP | disclosed |
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2023025307-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2023-03-02 | — | — | WO | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |