Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.42 |
| ▸ | CSF1R | P07333 | 8/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23301724 | 1.00 | EGFR (0.42) | EGFRCSF1RFGFR4CTSDCTSE | |
| SCHEMBL30194690 | 0.97 | FGFR4 (0.45) | EGFRCSF1RFGFR4CTSDCTSE | |
| SCHEMBL30194460 | 0.97 | FGFR4 (0.45) | EGFRCSF1RFGFR4CTSDCTSE | |
| SCHEMBL30194484 | 0.95 | FGFR4 (0.46) | EGFRCSF1RFGFR4USP30 | |
| SCHEMBL23301942 | 0.95 | FGFR4 (0.46) | EGFRCSF1RFGFR4USP30 | |
| SCHEMBL29895103 | 0.95 | FGFR4 (0.46) | EGFRCSF1RFGFR4USP30 | |
| SCHEMBL23301911 | 0.92 | FGFR4 (0.42) | EGFRCSF1RFGFR4FGFR1FGFR3 | |
| SCHEMBL29894171 | 0.92 | FGFR4 (0.42) | EGFRCSF1RFGFR4FGFR1FGFR3 | |
| SCHEMBL23301685 | 0.91 | FGFR1 (0.42) | EGFRCSF1RFGFR4FGFR1FGFR2 | |
| SCHEMBL29894175 | 0.91 | FGFR1 (0.42) | EGFRCSF1RFGFR4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4051677-B1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INDUCED KINASE SIK2 | CANCER RESEARCH TECH LTD (GB) | 2026-03-18 | — | — | EP | disclosed |
| US-12509457-B2 | Bicyclic nitrogen containing heterocycles as inhibitors of salt-induced kinase SIK2 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2025-12-30 | — | — | US | disclosed |
| US-20230014742-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INDUCED KINASE SIK2 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-01-19 | — | — | US | disclosed |
| EP-4051677-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INUCED KINASE SIK2 | Cancer Research Technology Limited (GB) | 2022-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014742-A1 | BICYCLIC NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF SALT-INDUCED KINASE SIK2 | SIK2, SIK1, SIK3 | EGFR 1693/4885CSF1R 1398/4885FGFR4 991/4885 |
| US-12509457-B2 | Bicyclic nitrogen containing heterocycles as inhibitors of salt-induced kinase SIK2 | SIK2, SIK1, SIK3 | EGFR 1167/4885CSF1R 1324/4885FGFR4 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.