Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300326 | 1.00 | PRMT5 (0.47) | PRMT5WDR77AAK1HCRTR1HCRTR2 | |
| SCHEMBL27118089 | 0.87 | PRMT5 (0.48) | PRMT5WDR77AAK1CA1CA9 | |
| SCHEMBL30874514 | 0.87 | CA1 (0.46) | CA1CA9CA2CA12CYP3A4 | |
| SCHEMBL21318698 | 0.87 | AAK1 (0.46) | PRMT5WDR77AAK1HCRTR1HCRTR2 | |
| SCHEMBL3319977 | 0.86 | PRMT5 (0.48) | PRMT5WDR77AAK1CA1CA9 | |
| SCHEMBL595545 | 0.85 | SIRT2 (0.47) | PRMT5WDR77AAK1SIRT2CYP3A4 | |
| SCHEMBL12567525 | 0.85 | AAK1 (0.48) | PRMT5WDR77AAK1CA1CA9 | |
| SCHEMBL30561474 | 0.85 | AAK1 (0.49) | PRMT5WDR77AAK1HCRTR1HCRTR2 | |
| SCHEMBL21030001 | 0.85 | AAK1 (0.49) | PRMT5WDR77AAK1HCRTR1HCRTR2 | |
| SCHEMBL3321460 | 0.85 | PRMT5 (0.46) | PRMT5WDR77AAK1CA1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023043292-A1 | PREPARATION METHOD FOR PYRIMIDINE-2-AMINE | 기초과학연구원 | 2023-03-23 | — | — | WO | disclosed |
| CN-110506044-B | BRD4 inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2022-07-05 | — | — | CN | disclosed |