Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 20/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | HCK | P08631 | 1/20 | 0.68 |
| ▸ | FGR | P09769 | 1/20 | 0.68 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.68 |
| ▸ | FLT4 | P35916 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.68 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.68 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21179082 | 1.00 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21179096 | 0.87 | RET (0.77) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL29897217 | 0.87 | RET (0.77) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL18518281 | 0.81 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL29572311 | 0.81 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21179023 | 0.80 | RET (1.00) | RET | |
| SCHEMBL29897240 | 0.80 | RET (1.00) | RET | |
| SCHEMBL21179043 | 0.79 | RET (1.00) | RET | |
| SCHEMBL21178990 | 0.79 | RET (1.00) | RET | |
| SCHEMBL21191266 | 0.79 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111615514-B | Substituted pyrazolo [4,3-C ] pyridine compounds as RET kinase inhibitors | 奥瑞生物药品公司 | 2022-10-11 | — | — | CN | disclosed |