Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 8/20 | 0.58 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | FECH | P22830 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624564 | 1.00 | CYP2C9 (0.58) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL27101338 | 0.89 | CYP2C9 (0.73) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL20400057 | 0.88 | MAP2K4 (0.70) | CYP2C9MAP2K4CYP3A4CYP2C19 | |
| SCHEMBL20408848 | 0.87 | MAP2K4 (0.73) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL29725811 | 0.87 | MAP2K4 (0.73) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL29898535 | 0.85 | CYP2C9 (0.61) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL21624536 | 0.85 | CYP2C9 (0.61) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL27101478 | 0.85 | MAP2K4 (0.59) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL29898532 | 0.85 | MAP2K4 (0.59) | CYP2C9MAP2K4CYP3A4CYP2C19RIPK2 | |
| SCHEMBL21624474 | 0.85 | CYP2C9 (0.63) | CYP2C9CYP3A4CYP2C19RIPK2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-09-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | MAPK4, MAPK7, MAPK14 | CYP2C9 1814/4885MAP2K4 22/4885CYP3A4 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.