Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.44 |
| ▸ | NEK2 | P51955 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.44 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.44 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624547 | 1.00 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL29898577 | 0.96 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL21624479 | 0.96 | CYP2C9 (0.52) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL23510279 | 0.89 | CYP2C9 (0.66) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL20408812 | 0.88 | MAP2K4 (0.56) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL20408819 | 0.88 | CYP2C9 (0.60) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL27101478 | 0.84 | MAP2K4 (0.59) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL29898532 | 0.84 | MAP2K4 (0.59) | CYP2C9CYP3A4CYP2C19MAP2K4BRAF | |
| SCHEMBL21624514 | 0.84 | BRAF (0.61) | CYP2C9CYP3A4CYP2C19BRAFRIPK2 | |
| SCHEMBL30866609 | 0.84 | BRAF (0.61) | CYP2C9CYP3A4CYP2C19BRAFRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-09-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220281864-A1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | MAPK4, MAPK7, MAPK14 | CYP2C9 1814/4885CYP3A4 667/4885CYP2C19 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.