Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 8/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.56 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.56 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.56 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888689 | 1.00 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23415350 | 1.00 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL17030855 | 0.90 | KIT (0.52) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16647233 | 0.89 | KIT (0.51) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16637040 | 0.86 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL24161929 | 0.86 | CNR1 (0.48) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL31658109 | 0.85 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128441 | 0.85 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23415335 | 0.84 | CNR1 (0.54) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL29901341 | 0.84 | CNR1 (0.54) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065231-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-10-05 | — | — | EP | disclosed |