Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 17/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461392 | 1.00 | STING1 (0.55) | STING1ALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23480416 | 0.84 | MAPK14 (0.38) | STING1BCL2L1HDAC3HDAC4HDAC1 | |
| SCHEMBL21405856 | 0.82 | STING1 (0.57) | STING1 | |
| SCHEMBL23480414 | 0.81 | BCL2L1 (0.58) | ALDH1A1BCL2L1HDAC3HDAC4HDAC1 | |
| SCHEMBL31463286 | 0.81 | STING1 (0.56) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11232455 | 0.78 | BCL2L1 (0.64) | STING1CYP1A2BCL2L1HDAC3HDAC4 | |
| SCHEMBL23462094 | 0.77 | STING1 (0.52) | STING1CYP1A2BCL2L1HDAC1 | |
| SCHEMBL31463236 | 0.77 | STING1 (0.67) | STING1ALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23461338 | 0.77 | STING1 (0.52) | STING1HDAC1 | |
| SCHEMBL29901448 | 0.77 | STING1 (0.52) | STING1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069683-A1 | DIMERIC COMPOUNDS AS STING AGONISTS | Mersana Therapeutics, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |