Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | TEC | P42680 | 1/20 | 0.57 |
| ▸ | TXK | P42681 | 1/20 | 0.57 |
| ▸ | BLK | P51451 | 1/20 | 0.57 |
| ▸ | BMX | P51813 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537866 | 1.00 | BTK (0.60) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL13860271 | 1.00 | BTK (0.60) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL16278362 | 0.91 | BTK (0.58) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL18647204 | 0.90 | BTK (0.70) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL30056791 | 0.90 | BTK (0.61) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL23834475 | 0.90 | BTK (0.61) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL22243313 | 0.89 | BTK (0.72) | BTKLCKLYNEGFRERBB2 | |
| SCHEMBL13860084 | 0.89 | BTK (0.59) | BTK | |
| SCHEMBL13860085 | 0.89 | BTK (0.59) | BTK | |
| SCHEMBL17235871 | 0.89 | BTK (0.70) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515687-A | Solid forms of 2- [3- [ 4-amino-3- (2-fluoro-4-phenoxy-phenyl) pyrazolo [3,4-D ] pyrimidin-1-yl ] piperidine-1-carbonyl ] -4-methyl-4- [4- (oxetan-3-yl) piperazin-1-yl ] pent-2-enenitrile | 普林斯匹亚生物制药公司 | 2022-12-23 | — | — | CN | disclosed |
| EP-4076670-A1 | SOLID FORMS OF 2-[3-[4-AMINO-3-(2-FLUORO-4-PHENOXY-PHENYL)PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL-4-[4-(OXETAN-3-YL)PIPERAZIN-1-YL]PENT-2-ENENITRILE | PRINCIPIA BIOPHARMA INC. (US) | 2022-10-26 | — | — | EP | disclosed |