Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896849 | 0.85 | EZH2 (0.38) | PARP1EZH2ALKSOS1PDE4A | |
| SCHEMBL24104463 | 0.82 | EZH2 (0.36) | PARP1EZH2ALKPDE4APDE4B | |
| SCHEMBL31115571 | 0.82 | EZH2 (0.36) | PARP1EZH2ALKPDE4APDE4B | |
| SCHEMBL24104464 | 0.78 | SOS1 (0.40) | SOS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30524585 | 0.76 | KDM4E (0.40) | PARP1EZH2ALKSOS1PDE4A | |
| SCHEMBL23520707 | 0.76 | SOS1 (0.47) | SOS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20327082 | 0.76 | SOS1 (0.47) | SOS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28779922 | 0.76 | KDM4E (0.40) | PARP1EZH2ALKSOS1PDE4A | |
| SCHEMBL28779926 | 0.76 | KDM4E (0.40) | PARP1EZH2ALKSOS1PDE4A | |
| SCHEMBL24104538 | 0.73 | SOS1 (0.39) | SOS1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028644-A | SOS1 inhibitor heterocyclic compounds | 首药控股(北京)股份有限公司 | 2022-09-09 | — | — | CN | disclosed |