Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992288 | 0.88 | IGF1R (0.49) | IGF1R | |
| SCHEMBL2940677 | 0.87 | IGF1R (0.55) | IGF1RPPARGPPARDPPARA | |
| SCHEMBL2943419 | 0.87 | IGF1R (0.55) | IGF1RPPARGPPARDPPARA | |
| SCHEMBL2941761 | 0.86 | IGF1R (0.55) | IGF1RPPARGPPARDPPARA | |
| SCHEMBL2943880 | 0.86 | IGF1R (0.49) | IGF1R | |
| SCHEMBL2942056 | 0.85 | IGF1R (0.53) | IGF1RPPARGPPARDPPARA | |
| SCHEMBL2981670 | 0.84 | IGF1R (0.48) | IGF1R | |
| SCHEMBL2995898 | 0.83 | IGF1R (0.51) | IGF1R | |
| SCHEMBL2941507 | 0.82 | IGF1R (0.51) | IGF1R | |
| SCHEMBL2934022 | 0.82 | IGF1R (0.49) | IGF1RNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |