Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.68 |
| ▸ | DNPH1 | O43598 | 8/20 | 0.65 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.65 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.65 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.65 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.65 |
| ▸ | LDHA | P00338 | 1/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | FBP1 | P09467 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.65 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988353 | 0.95 | P2RY12 (0.68) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL8916648 | 0.93 | P2RY12 (0.70) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL8352507 | 0.93 | P2RY12 (0.65) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL18274661 | 0.92 | P2RY12 (0.71) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL2990779 | 0.90 | P2RY12 (0.66) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL5545796 | 0.89 | P2RY12 (0.69) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL3193571 | 0.88 | P2RY12 (0.68) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL1933421 | 0.88 | P2RY12 (0.67) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL4997219 | 0.88 | P2RY12 (0.69) | P2RY12DNPH1P2RY1P2RY2TAS1R3 | |
| SCHEMBL6900642 | 0.87 | P2RY12 (0.75) | P2RY12DNPH1P2RY1P2RY2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708639-B2 | Method for quantifying amino acids with pyrophosphate | TOYAMA PREFECTURE (JP) | 2017-07-18 | — | — | US | disclosed |
| US-20140357524-A1 | Method for Quantifying Subject Substance | AJINOMOTO CO., INC. (JP) | 2014-12-04 | — | — | US | disclosed |
| WO-2013118894-A1 | METHOD FOR QUANTIFYING TARGET SUBSTANCE | 富山県 (JP) | 2013-08-15 | — | — | WO | disclosed |
| US-8183006-B2 | Screening method for identifying new aminoacyl-tRNA synthetase inhibitors | FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (ES) | 2012-05-22 | — | — | US | disclosed |
| US-7785827-B2 | Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules | UNIVERSITY OF HOUSTON SYSTEM (US) | 2010-08-31 | — | — | US | disclosed |
| EP-2064338-B1 | A SCREENING METHOD FOR IDENTIFYING NEW AMINOACYL-TRNA SYNTHETASE INHIBITORS | ICREA (ES) | 2010-04-07 | — | — | EP | disclosed |
| US-20100055719-A1 | Screening method for identifying new aminoacyl-tRNA synthetase inhibitors | FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA (ES) | 2010-03-04 | — | — | US | disclosed |
| EP-2064338-A1 | A SCREENING METHOD FOR IDENTIFYING NEW AMINOACYL-TRNA SYNTHETASE INHIBITORS | Institució Catalana de Recerca i Estudis Avançats (ES) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008028862-A1 | A SCREENING METHOD FOR IDENTIFYING NEW AMINOACYL-TRNA SYNTHETASE INHIBITORS | INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) (ES) | 2008-03-13 | — | — | WO | disclosed |
| US-20040203094-A1 | Eucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acids to tRNA adaptor molecules | BOARD OF REGENTS, UNIVERSITY OF HOUSTON | 2004-10-14 | — | — | US | disclosed |
| US-6631329-B1 | Complexed with mupirocin and tRNAile; streak-seedingm vapor equilibrating; replacing with cryoprotectant; flash-freezing | YALE UNIVERSITY | 2003-10-07 | — | — | US | disclosed |
| EP-1200564-A2 | USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN | YALE UNIVERSITY (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009154-A2 | USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN | YALE UNIVERSITY (US) | 2001-02-08 | — | — | WO | disclosed |
| WO-1994028139-A1 | tRNA BINDING-DEPENDENT INHIBITION OF MICROBIAL PATHOGEN GROWTH | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1994-12-08 | — | — | WO | disclosed |