Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734763 | 0.90 | GRM2 (0.65) | GRM2CYP3A4 | |
| SCHEMBL6738838 | 0.88 | GRM2 (0.62) | GRM2 | |
| SCHEMBL6732204 | 0.88 | GRM2 (0.78) | GRM2CYP3A4 | |
| SCHEMBL6733186 | 0.88 | GRM2 (0.78) | GRM2 | |
| SCHEMBL6727500 | 0.83 | GRM2 (0.69) | GRM2CYP3A4 | |
| SCHEMBL6733481 | 0.82 | GRM2 (0.65) | GRM2CYP3A4 | |
| SCHEMBL6735945 | 0.81 | GRM2 (0.78) | GRM2 | |
| SCHEMBL6733070 | 0.81 | GRM2 (0.60) | GRM2CYP3A4 | |
| SCHEMBL6733084 | 0.81 | GRM2 (0.80) | GRM2 | |
| SCHEMBL6738584 | 0.80 | GRM2 (0.47) | GRM2CYP3A4PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098030-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | UNIV VANDERBILT (US) | 2026-04-09 | — | — | US | disclosed |
| EP-4673136-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | Vanderbilt University (US) | 2026-01-07 | — | — | EP | disclosed |
| EP-4568944-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | Vanderbilt University (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024182692-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2024-09-06 | — | — | WO | disclosed |
| US-20240208983-A1 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY | 2024-06-27 | — | — | US | disclosed |
| US-20240199641-A1 | QUINAZOLINE-4(3H)-ONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | UNIV VANDERBILT (US) | 2024-06-20 | — | — | US | disclosed |
| US-20240199640-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY | 2024-06-20 | — | — | US | disclosed |
| US-20230126310-A1 | COMPOSITIONS FOR CORONAVIRUS INFECTION TREATMENT AND/OR PREVENTION | FRAUNHOFER GES FORSCHUNG (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11472806-B2 | Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors | DOMAIN THERAPEUTICS (FR) | 2022-10-18 | — | — | US | disclosed |
| WO-2022212815-A1 | QUINAZOLINE-4(3H)-ONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212818-A1 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022198003-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240199640-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRIN2A, GRIN2C | GRM2 1/4885CYP3A4 4028/4885PDK1 1934/4885 |
| US-20240199641-A1 | QUINAZOLINE-4(3H)-ONE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRIN2A, GRIN2C | GRM2 1/4885CYP3A4 2764/4885PDK1 1828/4885 |
| US-20260098030-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRM1, GRIN2C | GRM2 1/4885CYP3A4 2043/4885PDK1 2488/4885 |
| US-20240208983-A1 | 1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRM1, GRM3 | GRM2 1/4885CYP3A4 2530/4885PDK1 1174/4885 |
| US-11472806-B2 | Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors | GRM3, GRM1, GRM2 | GRM2 3/4885CYP3A4 2911/4885PDK1 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.