SCHEMBL29904264

SCHEMBL29904264

NC(=O)c1cnc(-c2ccc(C3(N)CCC3)cc2)c(-c2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 20/20 1.00
AKT2 P31751 17/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4674159 0.83 AKT1 (0.70) AKT1AKT2
SCHEMBL15183439 0.80 AKT1 (1.00) AKT1AKT2
Hydrochloric Acid SCHEMBL530618 0.79 AKT1 (0.98) AKT1AKT2
SCHEMBL15183442 0.78 AKT1 (1.00) AKT1AKT2
Hydrochloric Acid SCHEMBL526433 0.77 AKT1 (0.98) AKT1AKT2
SCHEMBL10280378 0.75 AKT1 (0.67) AKT1AKT2
SCHEMBL530989 0.73 AKT1 (1.00) AKT1AKT2
SCHEMBL538481 0.73 AKT1 (0.59) AKT1AKT2
SCHEMBL1351523 0.73 AKT1 (0.62) AKT1AKT2
SCHEMBL16564541 0.73 AKT1 (0.88) AKT1AKT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250171465-A1 AKT INHIBITORS Stablix, Inc. 2025-05-29 US disclosed
EP-4066823-B1 REDUCED CALORIC INTAKE AND ANTICANCER AGENTS FOR THE TREATMENT OF CANCER IFOM ST FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS (IT) 2025-04-30 EP disclosed
WO-2024264070-A2 AKT INHIBITORS Stablix, Inc. (US) 2024-12-26 WO disclosed
US-20220313694-A1 REDUCED CALORIC INTAKE AND ANTICANCER AGENTS FOR THE TREATMENT OF CANCER IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) 2022-10-06 US disclosed
EP-4066823-A1 REDUCED CALORIC INTAKE AND ANTICANCER AGENTS FOR THE TREATMENT OF CANCER IFOM Fondazione Istituto Firc di Oncologia Molecolare (IT) 2022-10-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171465-A1 AKT INHIBITORS PIK3CA, PIK3CD, PIK3CG AKT1 5/4885AKT2 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.