Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.81 |
| ▸ | RET | P07949 | 10/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.68 |
| ▸ | ABL1 | P00519 | 10/20 | 0.68 |
| ▸ | SRC | P12931 | 10/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.68 |
| ▸ | PRKDC | P78527 | 10/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.68 |
| ▸ | EGFR | P00533 | 9/20 | 0.68 |
| ▸ | HCK | P08631 | 9/20 | 0.68 |
| ▸ | MTOR | P42345 | 9/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534730 | 1.00 | KDR (0.81) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL20535281 | 0.90 | KDR (1.00) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL20534669 | 0.86 | RET (1.00) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL20534933 | 0.86 | KDR (1.00) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL25858099 | 0.86 | RET (0.86) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL24907281 | 0.86 | KDR (0.73) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL29677750 | 0.85 | RET (1.00) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL21958123 | 0.85 | RET (1.00) | KDRRETPIK3CDABL1SRC | |
| SCHEMBL29904436 | 0.84 | RET (0.85) | KDRRET | |
| SCHEMBL20534665 | 0.84 | RET (0.85) | KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115785100-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-115785100-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-115785100-A | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-110506043-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2022-11-01 | — | — | CN | disclosed |