Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 5/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.58 |
| ▸ | ROS1 | P08922 | 7/20 | 0.58 |
| ▸ | INSR | P06213 | 4/20 | 0.56 |
| ▸ | IGF1R | P08069 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906810 | 1.00 | ZAP70 (0.66) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL26906797 | 0.85 | ALK (0.68) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL29904661 | 0.83 | ALK (0.65) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL29114856 | 0.83 | ALK (0.65) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL1912071 | 0.83 | ZAP70 (0.75) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL12892800 | 0.83 | ZAP70 (0.80) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL12729243 | 0.83 | ZAP70 (0.75) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL12729799 | 0.82 | ZAP70 (0.59) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL1912125 | 0.82 | ZAP70 (0.59) | ZAP70ALKROS1INSRIGF1R | |
| SCHEMBL29904630 | 0.81 | ALK (0.78) | ALKROS1INSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |