Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.63 |
| ▸ | INSR | P06213 | 3/20 | 0.61 |
| ▸ | IGF1R | P08069 | 3/20 | 0.61 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906790 | 1.00 | EGFR (0.75) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL29609251 | 0.86 | EGFR (1.00) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL21847015 | 0.86 | EGFR (1.00) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL26906834 | 0.84 | ALK (0.65) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL26906933 | 0.84 | EGFR (0.76) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL29904660 | 0.84 | EGFR (0.76) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL24255898 | 0.83 | EGFR (0.80) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL27076036 | 0.82 | EGFR (0.74) | EGFRALKLRRK2 | |
| SCHEMBL26906784 | 0.81 | EGFR (0.59) | EGFRALKLRRK2INSRIGF1R | |
| SCHEMBL18843516 | 0.81 | ALK (1.00) | EGFRALKLRRK2INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| CN-117120424-A | Pyrimidine derivatives having protein kinase inhibitory activity and therapeutic combinations comprising the same | 泰拉佩克斯有限公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |