Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.37 |
| ▸ | INSR | P06213 | 4/20 | 0.37 |
| ▸ | IGF1R | P08069 | 4/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906780 | 1.00 | EGFR (0.42) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26906903 | 0.92 | EGFR (0.44) | EGFRKCNH2CCNT1CDK4CCND1 | |
| SCHEMBL29114858 | 0.91 | EGFR (0.43) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26906899 | 0.84 | EGFR (0.49) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26907013 | 0.83 | ALK (0.52) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26906727 | 0.83 | ALK (0.50) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29904674 | 0.83 | ALK (0.50) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29114849 | 0.75 | EGFR (0.51) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29114867 | 0.74 | ALK (0.53) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29904646 | 0.74 | EGFR (0.62) | EGFRMETALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |