Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.65 |
| ▸ | INSR | P06213 | 14/20 | 0.65 |
| ▸ | IGF1R | P08069 | 12/20 | 0.65 |
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.62 |
| ▸ | MET | P08581 | 3/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | STK10 | O94804 | 2/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | FYN | P06241 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906710 | 1.00 | ALK (0.65) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906628 | 0.88 | ALK (0.75) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906797 | 0.88 | ALK (0.68) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906661 | 0.86 | ALK (0.87) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906646 | 0.83 | EGFR (0.66) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906731 | 0.82 | EGFR (0.65) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL30659706 | 0.82 | EGFR (0.54) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL26906878 | 0.81 | ALK (0.73) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL29114861 | 0.81 | ALK (0.66) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL12781316 | 0.81 | ALK (0.77) | ALKINSRIGF1REGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |