SCHEMBL299060

SCHEMBL299060

CCC(c1ccc(C(N)=O)c(C)c1C(=O)c1c[nH]c2ncc(-c3cccnc3)cc12)S(=O)(=O)O

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 2/20 0.42
BRD4 O60885 1/20 0.42
CYP2C9 P11712 4/20 0.41
CYP3A4 P08684 1/20 0.41
MKNK1 Q9BUB5 2/20 0.41
MKNK2 Q9HBH9 2/20 0.41
KCNH2 Q12809 3/20 0.41
ATM Q13315 2/20 0.41
CYP2C19 P33261 4/20 0.40
PDPK1 O15530 1/20 0.40
NEK1 Q96PY6 1/20 0.40
BRAF P15056 2/20 0.39
NTRK1 P04629 1/20 0.39
PIK3CA P42336 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297872 0.92 CYP2C9 (0.48) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL297658 0.86 DYRK1A (0.43) DYRK1ABRD4CYP2C9CYP3A4MKNK1
SCHEMBL413409 0.83 BRAF (0.49) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL298599 0.79 BRAF (0.58) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL3709343 0.79 NEK1 (0.52) DYRK1ABRD4MKNK1MKNK2PDPK1
SCHEMBL298841 0.78 CYP2C9 (0.58) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL294113 0.78 CYP2C9 (0.54) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL297931 0.78 BRAF (0.43) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL994632 0.77 BRAF (0.45) CYP2C9CYP3A4CYP2C19BRAF
SCHEMBL995687 0.76 BRAF (0.56) CYP2C9CYP3A4CYP2C19BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427433-A1 SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS Plexxikon, Inc. (US) 2012-03-14 EP disclosed