Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.47 |
| ▸ | RBP4 | P02753 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754195 | 1.00 | KLKB1 (0.47) | KLKB1RBP4KDM4AKDM5AKDM4C | |
| SCHEMBL29906548 | 0.87 | KLKB1 (0.47) | KLKB1RBP4KDM4AKDM5AKDM4C | |
| SCHEMBL23754076 | 0.87 | KLKB1 (0.49) | KLKB1RBP4RORC | |
| SCHEMBL23754318 | 0.87 | KLKB1 (0.47) | KLKB1RBP4KDM4AKDM5AKDM4C | |
| SCHEMBL29906573 | 0.86 | KLKB1 (0.45) | KLKB1 | |
| SCHEMBL23753982 | 0.86 | KLKB1 (0.45) | KLKB1 | |
| SCHEMBL29906588 | 0.84 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL23754316 | 0.84 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL23768864 | 0.80 | KLKB1 (0.45) | KLKB1RBP4USP30 | |
| SCHEMBL23830189 | 0.79 | KLKB1 (0.39) | KLKB1RBP4KDM4CUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120287-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-116120287-A | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115052873-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-13 | — | — | CN | disclosed |