Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 9/20 | 0.36 |
| ▸ | AXL | P30530 | 8/20 | 0.36 |
| ▸ | MERTK | Q12866 | 6/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23211006 | 1.00 | TYRO3 (0.36) | TYRO3AXLMERTKPFKFB3HDAC8 | |
| SCHEMBL23210979 | 0.82 | TYRO3 (0.39) | TYRO3AXLMERTKPFKFB3 | |
| SCHEMBL29907078 | 0.82 | TYRO3 (0.39) | TYRO3AXLMERTKPFKFB3 | |
| SCHEMBL23249325 | 0.78 | NTRK1 (0.32) | TYRO3AXLMERTKNTRK1 | |
| SCHEMBL23210952 | 0.76 | TYRO3 (0.40) | TYRO3AXLMERTK | |
| SCHEMBL29906967 | 0.76 | MAP4K1 (0.49) | AXLMAP4K1 | |
| SCHEMBL23210831 | 0.76 | MAP4K1 (0.49) | AXLMAP4K1 | |
| SCHEMBL23211013 | 0.72 | KDM4E (0.40) | TYRO3AXLMERTK | |
| SCHEMBL30308766 | 0.69 | MAPK1 (0.34) | — | |
| SCHEMBL30308884 | 0.68 | MAPK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |