Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907186 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23211000 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29907129 | 0.97 | HPGD (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23211125 | 0.97 | HPGD (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30308816 | 0.97 | HPGD (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23210840 | 0.93 | RET (0.35) | ALDH1A1LMNARET | |
| SCHEMBL30308850 | 0.90 | DPP4 (0.35) | USP30RET | |
| SCHEMBL23211137 | 0.90 | RET (0.35) | KMT2ARET | |
| SCHEMBL30308756 | 0.90 | DPP4 (0.34) | MEN1KMT2AHTTMAPTNPSR1 | |
| SCHEMBL23211056 | 0.88 | KDM4E (0.39) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |