Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856462 | 1.00 | PARP1 (0.47) | PARP1HTR2AHTR2CDPP4ADORA2A | |
| SCHEMBL23124283 | 0.90 | PARP1 (0.45) | PARP1HTR2AHTR2CDPP4ADORA2A | |
| SCHEMBL556764 | 0.87 | PARP1 (0.51) | PARP1HTR2AHTR2CDPP4ADORA2A | |
| SCHEMBL3068250 | 0.82 | PARP1 (0.47) | PARP1HTR2AHTR2CDPP4ADORA2A | |
| SCHEMBL7846859 | 0.80 | PARP1 (0.50) | PARP1HTR2AHTR2CADORA2AADORA1 | |
| SCHEMBL7856329 | 0.79 | HTR2A (0.43) | PARP1HTR2AHTR2CDRD4DRD3 | |
| SCHEMBL6043794 | 0.79 | PARP1 (0.41) | PARP1HTR2AHTR2CDPP4ADORA2A | |
| SCHEMBL2820808 | 0.79 | PARP1 (0.56) | PARP1HTR2AHTR2CADORA2AADORA1 | |
| SCHEMBL31693421 | 0.78 | HTR2A (0.47) | PARP1HTR2AHTR2CADORA2ADRD3 | |
| SCHEMBL21941453 | 0.78 | HTR2A (0.42) | PARP1HTR2AHTR2CADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120035595-A | Thiazolo [5,4-d ] pyrimidine compounds, compositions comprising the same and uses thereof | 蒙特利尔大学 | 2025-05-23 | — | — | CN | disclosed |
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| CN-117177973-A | Pyrido [3,2-D ] pyrimidine compounds and their use for the treatment of proliferative disorders | 蒙特利尔大学 | 2023-12-05 | — | — | CN | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |