Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.63 |
| ▸ | NCOR2 | Q9Y618 | 8/20 | 0.63 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.59 |
| ▸ | MIF | P14174 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.50 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | PCLAF | Q15004 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29908946 | 1.00 | HDAC1 (0.63) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24881714 | 1.00 | HDAC1 (0.63) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24882089 | 0.94 | HDAC1 (0.66) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL29908942 | 0.91 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24881882 | 0.91 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL29908958 | 0.91 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24881467 | 0.91 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24880997 | 0.91 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24881470 | 0.89 | HDAC1 (0.66) | HDAC1HDAC3HDAC2NCOR2CRBN | |
| SCHEMBL24881054 | 0.89 | HDAC1 (0.62) | HDAC1HDAC3HDAC2NCOR2CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4054607-A1 | SELECTIVE HDAC6 DEGRADERS AND METHODS OF USE THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2022-09-14 | — | — | EP | disclosed |