Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577971 | 1.00 | PDE2A (0.39) | PDE2APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL23577118 | 0.82 | SMN1; SMN2 (0.38) | TP53TSHRSMN1; SMN2 | |
| SCHEMBL30961028 | 0.82 | SMN1; SMN2 (0.38) | TP53TSHRSMN1; SMN2 | |
| SCHEMBL23576722 | 0.81 | KMT2A (0.38) | TP53TSHRSMN1; SMN2KMT2A | |
| SCHEMBL29909886 | 0.81 | KMT2A (0.38) | TP53TSHRSMN1; SMN2KMT2A | |
| SCHEMBL23576996 | 0.81 | EED (0.36) | PDE2ATP53MAPK1SMN1; SMN2 | |
| SCHEMBL30013127 | 0.81 | SMN1; SMN2 (0.36) | TP53TSHRSMN1; SMN2 | |
| SCHEMBL23601767 | 0.80 | SMN1; SMN2 (0.37) | TP53SMN1; SMN2 | |
| SCHEMBL23577552 | 0.80 | MAPT (0.33) | EGFRTP53SMN1; SMN2 | |
| SCHEMBL29909139 | 0.80 | MAPT (0.33) | EGFRTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |