SCHEMBL29909890

SCHEMBL29909890

CN(c1cccc(-c2ccc(C(C)(C)C(=O)O)cc2)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.38
FNTB P49356 1/20 0.38
MAP4K4 O95819 2/20 0.36
CSNK2A2 P19784 1/20 0.35
CSNK2B P67870 1/20 0.35
MAP3K5 Q99683 2/20 0.35
PDE4B Q07343 1/20 0.35
PDE4D Q08499 1/20 0.35
SLC22A12 Q96S37 1/20 0.33
F10 P00742 1/20 0.33
DHODH Q02127 1/20 0.33
MAT2A P31153 4/20 0.33
PRMT5 O14744 2/20 0.33
CYP1A2 P05177 1/20 0.33
SGK1 O00141 2/20 0.33
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577248 1.00 FNTA (0.38) FNTAFNTBMAP4K4CSNK2A2CSNK2B
SCHEMBL23601858 0.93 FNTA (0.39) FNTAFNTBCSNK2A2CSNK2BPDE4B
SCHEMBL31229755 0.93 FNTA (0.39) FNTAFNTBCSNK2A2CSNK2BPDE4B
SCHEMBL23600548 0.90 FNTA (0.40) FNTAFNTBCSNK2A2CSNK2BF10
SCHEMBL31169406 0.90 FNTA (0.40) FNTAFNTBCSNK2A2CSNK2BF10
SCHEMBL23577059 0.89 FNTA (0.41) FNTAFNTBMAT2APRMT5CYP1A2
SCHEMBL29909922 0.89 FNTA (0.41) FNTAFNTBMAT2APRMT5CYP1A2
SCHEMBL31229690 0.88 FNTA (0.41) FNTAFNTBCSNK2A2CSNK2BDHODH
SCHEMBL23577102 0.88 FNTA (0.41) FNTAFNTBCSNK2A2CSNK2BDHODH
SCHEMBL31229732 0.88 CSNK2A2 (0.44) FNTAFNTBMAP4K4CSNK2A2CSNK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed