Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.65 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | COMT | P21964 | 3/20 | 0.48 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525134 | 0.83 | COMT (0.52) | HCAR2HCAR3KDM5ACOMTDAO | |
| SCHEMBL1739326 | 0.79 | HCAR2 (1.00) | HCAR2HCAR3KDM5ADAOMAPT | |
| SCHEMBL5599627 | 0.78 | HCAR2 (0.76) | HCAR2HCAR3KDM5ADAO | |
| Hydrochloric Acid SCHEMBL31467457 | 0.78 | HCAR2 (0.96) | HCAR2HCAR3KDM5ADAOMAPT | |
| SCHEMBL1149787 | 0.77 | HCAR2 (0.59) | HCAR2HCAR3KDM5ADAO | |
| SCHEMBL20515900 | 0.77 | HCAR2 (0.51) | HCAR2HCAR3KDM5ADAOMAPT | |
| SCHEMBL19763765 | 0.77 | HCAR2 (0.51) | HCAR2HCAR3KDM5ADAOMAPT | |
| SCHEMBL19763767 | 0.77 | HCAR2 (0.51) | HCAR2HCAR3KDM5ADAOMAPT | |
| SCHEMBL1149300 | 0.74 | HCAR2 (0.57) | HCAR2HCAR3DAO | |
| SCHEMBL1149303 | 0.74 | HCAR2 (0.57) | HCAR2HCAR3DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289751-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289751-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | KDM5A, KDM1B, KDM5D | HCAR2 2298/4885HCAR3 2618/4885KDM5A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.