Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 14/20 | 0.65 |
| ▸ | SMARCA2 | P51531 | 11/20 | 0.65 |
| ▸ | SMARCA4 | P51532 | 11/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21422087 | 1.00 | PBRM1 (0.65) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL23301773 | 0.99 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25618905 | 0.88 | PBRM1 (0.58) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL23302071 | 0.88 | PBRM1 (0.52) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL30147919 | 0.88 | PBRM1 (0.52) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL29943032 | 0.88 | PBRM1 (0.51) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25618329 | 0.83 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21456009 | 0.83 | PBRM1 (0.62) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21421572 | 0.83 | PBRM1 (0.71) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21404908 | 0.82 | SLC6A2 (0.48) | PBRM1SMARCA2SMARCA4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4054724-A1 | BIFUNCTIONAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2022-09-14 | — | — | EP | disclosed |
| EP-4051674-A1 | BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2022-09-07 | — | — | EP | disclosed |