Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20086108 | 1.00 | MAPT (0.60) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL11365005 | 0.80 | RECQL (0.50) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL11365001 | 0.80 | RECQL (0.50) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL25323807 | 0.78 | CYP1A2 (0.58) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL12501427 | 0.78 | MAPT (0.55) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL12501198 | 0.76 | MAPT (0.47) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL14651303 | 0.76 | MAPT (0.47) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL782731 | 0.76 | MAPT (1.00) | MAPTALDH1A1HPGDHTTLMNA | |
| SCHEMBL15849060 | 0.76 | DYRK1A (0.55) | ALDH1A1HPGDRAB9APOLBSMN1; SMN2 | |
| SCHEMBL29419236 | 0.76 | MAPT (1.00) | MAPTALDH1A1HPGDHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115531387-A | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-110234637-B | Pyrazole amide compounds useful as IRAK inhibitors | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | disclosed |