Sugi Predict

Sugi Predict / Compounds / SCHEMBL29912815

SCHEMBL29912815

SCHEMBL29912815

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NPY2R P49146 6/20 0.67
▸ NPY4R P50391 6/20 0.67
▸ NPY5R Q15761 6/20 0.67
▸ NPY1R P25929 4/20 0.67
▸ CXCR4 P61073 6/20 0.66
▸ KEAP1 Q14145 1/20 0.62
▸ EED O75530 1/20 0.60
▸ GLP1R P43220 3/20 0.59
▸ GCGR P47871 1/20 0.58
▸ GIPR P48546 1/20 0.58
▸ PTH1R Q03431 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30081077 0.95 NPY2R (0.67) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL29989757 0.93 NPY2R (0.67) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL29993338 0.92 NPY1R (0.67) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL29973066 0.91 NPY1R (0.66) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL30709702 0.91 NPY1R (0.66) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL31092058 0.90 CXCR4 (0.67) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL30456977 0.90 NPY1R (0.66) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL30176426 0.90 NPY1R (0.69) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL30658324 0.90 NPY2R (0.71) NPY2RNPY4RNPY5RNPY1RCXCR4
SCHEMBL31182815 0.90 NPY2R (0.73) NPY2RNPY4RNPY5RNPY1RCXCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250197861-A1 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF ALPHA-1 ANTITRYPSIN Arrowhead Pharmaceuticals, Inc. (US) 2025-06-19 — — US disclosed
EP-4527391-A2 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF ALPHA-1 ANTITRYPSIN Arrowhead Pharmaceuticals, Inc. (US) 2025-03-26 — — EP disclosed
EP-3157541-B1 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF ALPHA-1 ANTITRYPSIN ARROWHEAD PHARMACEUTICALS INC (US) 2025-02-12 — — EP disclosed
US-12188017-B2 Compositions and methods for inhibiting gene expression of alpha-1 antitrypsin Arrowhead Pharmaceuticals, Inc. (US) 2025-01-07 — — US disclosed
CN-113444725-B Compositions and methods for inhibiting alpha-1 antitrypsin gene expression 箭头药业股份有限公司 2024-08-13 — — CN disclosed
US-20230002768-A1 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF ALPHA-1 ANTITRYPSIN Arrowhead Pharmaceuticals, Inc. (US) 2023-01-05 — — US disclosed
US-11384355-B2 Compositions and methods for inhibiting gene expression of alpha-1 AntiTrypsin Arrowhead Pharmaceuticals, Inc. (US) 2022-07-12 — — US disclosed
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