Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.67 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 9/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680827 | 1.00 | FYN (0.67) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL29914458 | 0.86 | FYN (0.60) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL24681090 | 0.86 | FYN (0.60) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL24681351 | 0.85 | FYN (0.68) | FYNTGFBR1ACVR1 | |
| SCHEMBL24681043 | 0.85 | FYN (0.64) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL24680896 | 0.84 | FYN (0.61) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL29914547 | 0.82 | FYN (0.58) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL24681149 | 0.82 | FYN (0.58) | FYNTGFBR1ACVR1RIPK2NOD2 | |
| SCHEMBL2225829 | 0.80 | FYN (1.00) | FYNTGFBR1ACVR1 | |
| SCHEMBL18613336 | 0.80 | FYN (1.00) | FYNTGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |