Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.56 |
| ▸ | PARP11 | Q9NR21 | 9/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077798 | 1.00 | MAPK1 (0.63) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| Bromide SCHEMBL12077592 | 0.99 | MAPK1 (0.62) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| Bromide SCHEMBL12495769 | 0.88 | MAPK1 (0.52) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| SCHEMBL18113045 | 0.87 | PRKCI (0.49) | MAPK1PARP10PARP11MAPKAPK2GSK3B | |
| SCHEMBL20087312 | 0.85 | MAPK1 (0.63) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| SCHEMBL18113050 | 0.85 | PARP10 (0.56) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| SCHEMBL18123077 | 0.85 | MAPK1 (0.63) | MAPK1PARP10PARP11MAPKAPK2GSK3B | |
| SCHEMBL12090423 | 0.83 | PARP10 (0.53) | MAPK1PARP10PARP11PARP1MAPKAPK2 | |
| SCHEMBL24681233 | 0.82 | PARP10 (0.48) | MAPK1PARP10PARP11PARP1MKNK1 | |
| SCHEMBL29914493 | 0.82 | PARP10 (0.48) | MAPK1PARP10PARP11PARP1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |