Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914388 | 1.00 | MAPK1 (0.57) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL24680704 | 1.00 | MAPK1 (0.57) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL24680727 | 1.00 | MAPK1 (0.57) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL24681101 | 1.00 | MAPK1 (0.57) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL24680712 | 0.94 | MAPK1 (0.61) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL29914605 | 0.94 | MAPK1 (0.61) | MAPK1TGFBR1ACVR1MAPKAPK2CCNT1 | |
| SCHEMBL24680734 | 0.88 | MAPK1 (0.54) | MAPK1TGFBR1ACVR1MAPKAPK2FYN | |
| SCHEMBL24680869 | 0.88 | MAPK1 (0.54) | MAPK1TGFBR1ACVR1MAPKAPK2GSK3B | |
| SCHEMBL24681104 | 0.88 | MAPK1 (0.54) | MAPK1TGFBR1ACVR1MAPKAPK2GSK3B | |
| SCHEMBL24680768 | 0.88 | MAPK1 (0.54) | MAPK1TGFBR1ACVR1MAPKAPK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |