Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680769 | 1.00 | MAPK1 (0.54) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL29914584 | 0.90 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL29914401 | 0.90 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11GSK3B | |
| SCHEMBL24681079 | 0.90 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL24681080 | 0.90 | MAPK1 (0.51) | MAPK1MAPKAPK2PARP10PARP11GSK3B | |
| SCHEMBL24681229 | 0.85 | MAPK1 (0.60) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL29914496 | 0.85 | MAPK1 (0.60) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL29964192 | 0.85 | MAPK1 (0.44) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL24680933 | 0.85 | MAPK1 (0.55) | MAPK1MAPKAPK2PARP10PARP11CDK4 | |
| SCHEMBL29914601 | 0.85 | MAPK1 (0.55) | MAPK1MAPKAPK2PARP10PARP11CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |