Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.44 |
| ▸ | PARP11 | Q9NR21 | 8/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681339 | 1.00 | MAPK1 (0.59) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29914489 | 0.86 | MAPK1 (0.63) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL24681332 | 0.86 | MAPK1 (0.63) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29914491 | 0.83 | MAPK1 (0.67) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29965170 | 0.83 | MAPK1 (0.48) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL24681135 | 0.83 | MAPK1 (0.61) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL29914392 | 0.83 | MAPK1 (0.61) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL18936971 | 0.80 | MAPK1 (0.60) | MAPK1PARP10PARP11MAPKAPK2MAPK9 | |
| SCHEMBL24681000 | 0.80 | MAPK1 (0.65) | MAPK1PARP10PARP11GSK3BMAPKAPK2 | |
| SCHEMBL24681152 | 0.80 | MAPK1 (0.65) | MAPK1PARP10PARP11GSK3BMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |