Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 20/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22619493 | 1.00 | GRM5 (0.83) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL22619487 | 0.91 | GRM5 (1.00) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL22619510 | 0.89 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915426 | 0.89 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915481 | 0.89 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL20616680 | 0.89 | GRM5 (0.78) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915431 | 0.88 | GRM5 (0.66) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL22619541 | 0.88 | GRM5 (0.66) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL22619499 | 0.88 | GRM5 (0.84) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL29915444 | 0.88 | GRM5 (0.84) | GRM5CYP1A2CYP3A4CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4584250-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (VG) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054811-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | Recordati Industria Chimica e Farmacentica S.p.A. (IT) | 2022-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | GRM5, GRIK5, GRM2 | GRM5 1/4885CYP1A2 3556/4885CYP3A4 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.