Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915493 | 0.87 | GRM5 (0.41) | GRM5NR1H2USP2SMN1; SMN2 | |
| SCHEMBL29915494 | 0.84 | GRM5 (0.66) | GRM5 | |
| SCHEMBL29915379 | 0.83 | GRM5 (0.43) | GRM5NR1H2USP2SMN1; SMN2 | |
| SCHEMBL22613620 | 0.82 | GRM5 (0.46) | GRM5 | |
| SCHEMBL29915467 | 0.81 | GRM5 (0.47) | GRM5NR1H2USP2SMN1; SMN2 | |
| SCHEMBL513283 | 0.80 | GRM5 (0.61) | GRM5USP2SMN1; SMN2 | |
| SCHEMBL29915323 | 0.80 | GRM5 (0.42) | GRM5NR1H2 | |
| SCHEMBL22619484 | 0.79 | GRM5 (0.79) | GRM5 | |
| SCHEMBL29915399 | 0.78 | NR1H2 (0.42) | GRM5NR1H2USP2SMN1; SMN2 | |
| SCHEMBL3639664 | 0.78 | GRM5 (0.53) | GRM5NR1H2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | Recordati Industria Chimica e Farmacentica S.p.A. (IT) | 2022-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | GRM5, GRIK5, GRM2 | GRM5 1/4885NR1H2 342/4885USP2 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.