Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 19/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367953 | 0.94 | AKR1B1 (0.41) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL19140389 | 0.86 | AKR1B1 (0.38) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL360713 | 0.80 | AKR1B1 (0.64) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL369867 | 0.80 | AKR1B1 (0.42) | AKR1B1 | |
| SCHEMBL15206300 | 0.76 | AKR1B1 (0.55) | AKR1B1 | |
| SCHEMBL10065363 | 0.75 | AKR1B1 (0.51) | AKR1B1 | |
| SCHEMBL18265843 | 0.72 | AKR1B1 (0.39) | AKR1B1 | |
| SCHEMBL19726781 | 0.72 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9374539 | 0.71 | AKR1B1 (0.79) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL362133 | 0.70 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4124620-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2023-02-01 | — | — | EP | disclosed |
| EP-3597650-B1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | UNIV COLUMBIA (US) | 2022-09-07 | — | — | EP | disclosed |