Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.56 |
| ▸ | EIF4A1 | P60842 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23576326 | 1.00 | DHODH (0.70) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL26076029 | 0.92 | DHODH (0.59) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL23590070 | 0.92 | DHODH (0.68) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL29918716 | 0.92 | DHODH (0.58) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL23576324 | 0.92 | DHODH (0.58) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL23590082 | 0.91 | DHODH (0.69) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL29997228 | 0.91 | DHODH (0.62) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL23580018 | 0.91 | DHODH (0.62) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL29617661 | 0.90 | DHODH (0.66) | DHODHPDE10AMEN1KMT2APLA2G2A | |
| SCHEMBL23590073 | 0.90 | DHODH (0.66) | DHODHPDE10AMEN1KMT2APLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025227007-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2025-10-30 | — | — | WO | disclosed |
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2024-10-03 | — | — | US | disclosed |
| CN-117915938-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 47-sirpa therapeutic agents | 俄亥俄州国家创新基金会 | 2024-04-19 | — | — | CN | disclosed |
| CN-115335052-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 38 therapeutics | 俄亥俄州国家创新基金会 | 2022-11-11 | — | — | CN | disclosed |
| EP-4081219-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | DHODH, CD47, IDH1 | DHODH 1/4885PDE10A 3913/4885MEN1 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.