SCHEMBL29920459

SCHEMBL29920459

CCNc1cnc(N2Cc3c(cc(CO)cc3C(F)(F)F)C2=O)cc1-c1ccc(F)cc1-c1nncn1C

nearest known ligand 0.42

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CBLB Q13191 20/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27086236 1.00 CBLB (0.42) CBLB
SCHEMBL29192858 0.89 CBLB (0.40) CBLB
SCHEMBL27086297 0.84 CBLB (0.51) CBLB
SCHEMBL29920430 0.84 CBLB (0.51) CBLB
SCHEMBL27086529 0.83 CBLB (0.39) CBLB
SCHEMBL29920849 0.83 CBLB (0.39) CBLB
SCHEMBL30825436 0.80 CBLB (0.49) CBLB
SCHEMBL27086354 0.80 CBLB (0.49) CBLB
SCHEMBL30825408 0.79 CBLB (0.51) CBLB
SCHEMBL27086199 0.79 CBLB (0.51) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858707-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 CN disclosed
EP-4319756-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-02-14 EP disclosed
WO-2022217276-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-10-13 WO disclosed