Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | IDH1 | O75874 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17798058 | 1.00 | EPHX2 (0.56) | EPHX2IDH1MAPK1CYP11B1CYP11B2 | |
| SCHEMBL1884654 | 0.78 | CYP11B1 (0.65) | EPHX2CYP11B1CYP11B2HDAC8HDAC2 | |
| SCHEMBL29920844 | 0.77 | BRD4 (0.63) | EPHX2CREBBPBRD4 | |
| SCHEMBL17798161 | 0.77 | BRD4 (0.63) | EPHX2CREBBPBRD4 | |
| SCHEMBL6541692 | 0.77 | EPHX2 (0.62) | EPHX2CYP11B1CYP11B2HDAC8HDAC2 | |
| SCHEMBL6541718 | 0.74 | EPHX2 (0.70) | EPHX2MAPK1HDAC8HDAC2HDAC6 | |
| SCHEMBL24200101 | 0.73 | EPHX2 (1.00) | EPHX2MAPK1HDAC8HDAC2HDAC6 | |
| SCHEMBL29778121 | 0.73 | EPHX2 (1.00) | EPHX2MAPK1HDAC8HDAC2HDAC6 | |
| SCHEMBL17131074 | 0.73 | EPHX2 (0.51) | EPHX2MAPK1CYP11B1CYP11B2RET | |
| SCHEMBL14552638 | 0.67 | EPHX2 (0.51) | EPHX2MAPK1HDAC8HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446306-B2 | Bicyclic bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11446306-B2 | Bicyclic bromodomain inhibitors | BRD4, BRD3, BRD2 | EPHX2 2831/4885IDH1 1000/4885MAPK1 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.