SCHEMBL299207

SCHEMBL299207

CN1C(=O)COc2ccc(-c3ccc(CC(C#N)NC(=O)C4CCOCC4)cc3)cc21

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSC P53634 20/20 0.69
CTSK P43235 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL289370 0.87 CTSC (0.72) CTSCCTSK
SCHEMBL299869 0.84 CTSC (0.62) CTSCCTSK
SCHEMBL2888632 0.84 CTSC (0.77) CTSCCTSK
SCHEMBL2888637 0.84 CTSC (0.77) CTSCCTSK
SCHEMBL298828 0.82 CTSC (0.61) CTSCCTSK
SCHEMBL20162042 0.81 CTSC (1.00) CTSC
SCHEMBL16932342 0.81 CTSC (1.00) CTSC
SCHEMBL29433601 0.81 CTSC (1.00) CTSC
Trifluoroacetic Acid SCHEMBL2890511 0.80 CTSC (0.71) CTSCCTSK
SCHEMBL9886042 0.79 CTSC (0.56) CTSCCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427445-A1 SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 AstraZeneca AB (SE) 2012-03-14 EP claimed
EP-2427445-A1 SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 AstraZeneca AB (SE) 2012-03-14 EP disclosed