Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.63 |
| ▸ | BCR | P11274 | 8/20 | 0.63 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 4/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29071524 | 1.00 | ABL1 (0.63) | ABL1BCRGPR142CSF1RRAF1 | |
| SCHEMBL29921892 | 0.94 | ABL1 (0.72) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29071349 | 0.94 | ABL1 (0.72) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29921674 | 0.86 | ABL1 (0.59) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29071240 | 0.86 | ABL1 (0.59) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29071277 | 0.86 | ABL1 (0.57) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29921977 | 0.86 | ABL1 (0.61) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29071312 | 0.86 | ABL1 (0.61) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29071512 | 0.85 | ABL1 (0.60) | ABL1BCRCSF1RRAF1BRAF | |
| SCHEMBL29921869 | 0.85 | ABL1 (0.60) | ABL1BCRCSF1RRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022188792-A1 | HETEROCYCLIC COMPOUND HAVING PROTEIN KINASE INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |