Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.54 |
| ▸ | BCR | P11274 | 12/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29071286 | 1.00 | ABL1 (0.54) | ABL1BCRBRAFRAF1RIPK1 | |
| SCHEMBL29071292 | 0.90 | ABL1 (0.57) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29921432 | 0.90 | ABL1 (0.57) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29921888 | 0.83 | ABL1 (0.46) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29921615 | 0.82 | ABL1 (0.52) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29071237 | 0.82 | ABL1 (0.52) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29071268 | 0.81 | ABL1 (0.49) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29921343 | 0.81 | ABL1 (0.49) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29921977 | 0.77 | ABL1 (0.61) | ABL1BCRBRAFRAF1 | |
| SCHEMBL29071312 | 0.77 | ABL1 (0.61) | ABL1BCRBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022188792-A1 | HETEROCYCLIC COMPOUND HAVING PROTEIN KINASE INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |