Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 8/20 | 0.42 |
| ▸ | BCR | P11274 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29071260 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9AABL1BCRNPC1 | |
| SCHEMBL29921788 | 0.89 | ABL1 (0.42) | ABL1BCRTEK | |
| SCHEMBL29071282 | 0.89 | ABL1 (0.42) | ABL1BCRTEK | |
| SCHEMBL29071319 | 0.88 | ABL1 (0.56) | ABL1BCRGAACSF1R | |
| SCHEMBL29071497 | 0.88 | ABL1 (0.42) | ABL1BCR | |
| SCHEMBL29921498 | 0.88 | ABL1 (0.42) | ABL1BCR | |
| SCHEMBL29921912 | 0.88 | ABL1 (0.56) | ABL1BCRGAACSF1R | |
| SCHEMBL29921318 | 0.86 | ABL1 (0.39) | SMN1; SMN2RAB9AABL1BCRNPC1 | |
| SCHEMBL29921947 | 0.81 | ABL1 (0.46) | ABL1BCRCSF1R | |
| SCHEMBL29071235 | 0.81 | ABL1 (0.51) | ABL1BCRTEKALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022188792-A1 | HETEROCYCLIC COMPOUND HAVING PROTEIN KINASE INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |