Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.54 |
| ▸ | BRD4 | O60885 | 10/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | IL1B | P01584 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17873763 | 1.00 | CRBN (0.54) | CRBNBRD4IKZF1TNFIL1B | |
| Trifluoroacetic Acid SCHEMBL17873750 | 1.00 | CRBN (0.54) | CRBNBRD4IKZF1TNFIL1B | |
| Trifluoroacetic Acid SCHEMBL29922014 | 1.00 | CRBN (0.54) | CRBNBRD4IKZF1TNFIL1B | |
| Trifluoroacetic Acid SCHEMBL29922473 | 0.99 | CRBN (0.54) | CRBNBRD4IKZF1TNFIL1B | |
| Trifluoroacetic Acid SCHEMBL17873758 | 0.99 | CRBN (0.54) | CRBNBRD4IKZF1TNFIL1B | |
| Trifluoroacetic Acid SCHEMBL30045679 | 0.97 | CRBN (0.55) | CRBNBRD4IKZF1TNFIL1B | |
| SCHEMBL17873770 | 0.94 | CRBN (0.58) | CRBNBRD4IKZF1TNFIL1B | |
| SCHEMBL31526908 | 0.94 | CRBN (0.58) | CRBNBRD4IKZF1TNFIL1B | |
| SCHEMBL30786799 | 0.94 | CRBN (0.58) | CRBNBRD4IKZF1TNFIL1B | |
| SCHEMBL31526946 | 0.94 | CRBN (0.58) | CRBNBRD4IKZF1TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108350062-B | Targeted protein degradation to attenuate adverse inflammatory responses associated with adoptive T cell therapy | 达纳-法伯癌症研究所股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| EP-3331905-B1 | TARGETED PROTEIN DEGRADATION TO ATTENUATE ADOPTIVE T-CELL THERAPY ASSOCIATED ADVERSE INFLAMMATORY RESPONSES | DANA FARBER CANCER INST INC (US) | 2022-10-05 | — | — | EP | disclosed |