Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922120 | 0.82 | TP53BP1 (0.45) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6400748 | 0.81 | CYP2C19 (0.53) | SMN1; SMN2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL16451199 | 0.79 | PARP1 (0.57) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL4656482 | 0.77 | PARP1 (0.63) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL9559865 | 0.76 | PARP1 (0.58) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL16449234 | 0.76 | PARP1 (0.53) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6399354 | 0.76 | TP53 (0.58) | LMNASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL16183174 | 0.73 | CYP2C19 (0.50) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL30673452 | 0.73 | CYP2C19 (0.50) | TP53BP1PARP1LMNASMN1; SMN2MEN1 | |
| SCHEMBL5255871 | 0.73 | PARP1 (0.50) | TP53BP1PARP1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188735-A1 | HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-09-15 | — | — | WO | disclosed |